Renna G, Cagiano R, Fiore T, Cuomo V
Pharmacol Res Commun. 1986 May;18(5):451-7. doi: 10.1016/0031-6989(86)90165-7.
Spectinomycin displays a dose-dependent neuromuscular blocking activity in vivo. The neuromuscular blockade elicited by spectinomycin is potentiated by d-tubocurarine. Neostigmine methylsulfate is unable to reverse the neuromuscular blocking activity of spectinomycin, whereas calcium chloride counteracts the neuromuscular blockade induced by this antibiotic.
大观霉素在体内表现出剂量依赖性的神经肌肉阻断活性。大观霉素引起的神经肌肉阻滞可被筒箭毒碱增强。新斯的明不能逆转大观霉素的神经肌肉阻断活性，而氯化钙可对抗这种抗生素诱导的神经肌肉阻滞。
