Albrecht P, Lorenz D, Klutch M J, Vickers J H, Ennis F A
Infect Immun. 1980 Mar;27(3):969-78. doi: 10.1128/iai.27.3.969-978.1980.
Moustached marmosets (Saguinus mystax) were infected intranasally with either of two low-passaged, wildlike strains of measles virus, strain Edmonston or strain JM. The infection resulted in 25 and 100% mortality, respectively, 12 to 14 days after infection. Clinical signs, gross pathological findings, and histology lacked the characteristic features of measles in other primates. A deficient immune response and widespread gastroenterocolitis appeared to be the main causes for the fatal outcome. Fluorescent-antibody staining detected large amounts of measles antigen in lymphatic tissues, the gastrointestinal and respiratory tracts, the salivary glands, pancreas, liver, kidney, and other visceral tissues. Live attenuated or inactivated measles vaccine proved equally effective in preventing fatal measles in marmosets. Challenge with live virus of animals which were primed 1 year previously with inactivated alum-absorbed vaccine resulted in a precipitous response, with a 100- to 1,000-fold increase in antibody titers. This vigorous booster response suggests the existence of a primary deficiency in lymphocyte cooperation in marmosets, which upon adequate priming is followed by extensive clonal expansion and antibody synthesis. Marmosets appear to be the most susceptible primate species to measles infection. They are capable of distinguishing differences in virulence of virus strains with a level of sensitivity not available in other animals.
有髭狨猴（Saguinus mystax）经鼻内接种两种低传代、类似野生型的麻疹病毒株之一，即埃德蒙斯顿株或JM株。感染后12至14天，死亡率分别为25%和100%。临床症状、大体病理发现和组织学均缺乏其他灵长类动物麻疹的特征性表现。免疫反应缺陷和广泛的胃肠炎似乎是导致致命结局的主要原因。荧光抗体染色在淋巴组织、胃肠道和呼吸道、唾液腺、胰腺、肝脏、肾脏及其他内脏组织中检测到大量麻疹抗原。减毒活疫苗或灭活麻疹疫苗在预防有髭狨猴致命性麻疹方面同样有效。用1年前接种灭活明矾吸附疫苗的动物进行活病毒攻击，会引发急剧反应，抗体滴度增加100至1000倍。这种强烈的加强反应表明有髭狨猴存在淋巴细胞协同作用的原发性缺陷，在充分致敏后会伴随广泛的克隆扩增和抗体合成。有髭狨猴似乎是对麻疹感染最易感的灵长类动物物种。它们能够以其他动物所没有的敏感性水平区分病毒株毒力的差异。
