Kaul Artur, Schönmann Uwe, Pöhlmann Stefan
Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
Laboratory Animal Sciences Unit, German Primate Center, 37077 Göttingen, Germany.
Primate Biol. 2019 Mar 26;6(1):1-6. doi: 10.5194/pb-6-1-2019. eCollection 2019.
Macaques serve as important animal models for biomedical research. Viral infection of macaques can compromise animal health as well as the results of biomedical research, and infected animals constitute an occupational health risk. Therefore, monitoring macaque colonies for viral infection is an important task. We used a commercial chip-based assay to analyze sera of 231 macaques for the presence of antibody responses against nine animal and human viruses. We report high seroprevalence of cytomegalovirus (CMV), lymphocryptovirus (LCV), rhesus rhadinovirus (RRV) and simian foamy virus (SFV) antibodies in all age groups. In contrast, antibodies against simian retrovirus type D (SRV/D) and simian T cell leukemia virus (STLV) were detected only in 5 % and 10 % of animals, respectively, and were only found in adult or aged animals. Moreover, none of the animals had antibodies against herpes B virus (BV), in keeping with the results of in-house tests previously used for screening. Finally, an increased seroprevalence of measles virus antibodies in animals with extensive exposure to multiple humans for extended periods of time was observed. However, most of these animals were obtained from external sources, and a lack of information on the measles antibody status of the animals at the time of arrival precluded drawing reliable conclusions from the data. In sum, we show, that in the colony studied, CMV, LCV, RRV and SFV infection was ubiquitous and likely acquired early in life while SRV/D and STLV infection was rare and likely acquired during adulthood.
猕猴是生物医学研究的重要动物模型。猕猴的病毒感染会损害动物健康以及生物医学研究的结果，并且受感染的动物构成职业健康风险。因此，监测猕猴群体的病毒感染是一项重要任务。我们使用基于芯片的商业检测方法分析了231只猕猴的血清，以检测针对9种动物和人类病毒的抗体反应。我们报告了在所有年龄组中巨细胞病毒（CMV）、淋巴隐病毒（LCV）、恒河猴疱疹病毒（RRV）和猿泡沫病毒（SFV）抗体的高血清阳性率。相比之下，仅在5%和10%的动物中分别检测到了抗D型猿猴逆转录病毒（SRV/D）和猿猴T细胞白血病病毒（STLV）的抗体，且仅在成年或老年动物中发现。此外，没有动物具有抗B病毒（BV）的抗体，这与先前用于筛查的内部检测结果一致。最后，观察到在长时间大量接触多个人类的动物中麻疹病毒抗体的血清阳性率增加。然而，这些动物大多数是从外部来源获得的，并且在到达时缺乏关于动物麻疹抗体状态的信息，因此无法从数据中得出可靠结论。总之，我们表明，在所研究的群体中，CMV、LCV、RRV和SFV感染普遍存在，且可能在生命早期获得，而SRV/D和STLV感染很少见，且可能在成年期获得。
