Rotman A, Caplan R, Szekely G A
Psychopharmacology (Berl). 1980;67(3):245-8. doi: 10.1007/BF00431264.
Platelet serotonin (5-HT) uptake was assayed in ten long-term hospitalized children subdivided into two diagnostic groups "autistic" and "other psychotic". Weekly blood samples were taken from these children over a period of 6-7 weeks and serotonin uptake was determined. Constant and significant uptake values (13.28 +/- 2.0 pmol serotonin/10(8) platelets/5 min for autistics and 9.59 +/- 1.58 pmol serotonin/10(8) platelets/5 min for other psychotics) were obtained. There was no correlation with drug treatment or with behavioral fluctuations in individual children. Three weekly uptake assays performed on six parents suggest the possible importance of genetic factors in these diseases. Biochemical-kinetic methodological problems of platelet 5-HT assessment are discussed.
对10名长期住院儿童的血小板血清素（5-羟色胺，5-HT）摄取情况进行了测定，这些儿童被分为两个诊断组：“自闭症”组和“其他精神病性障碍”组。在6至7周的时间里，每周从这些儿童身上采集血样，并测定血清素摄取量。获得了稳定且显著的摄取值（自闭症儿童为13.28±2.0皮摩尔血清素/10⁸血小板/5分钟，其他精神病性障碍儿童为9.59±1.58皮摩尔血清素/10⁸血小板/5分钟）。这与药物治疗或个别儿童的行为波动无关。对6名家长进行的每周三次摄取测定表明，遗传因素在这些疾病中可能具有重要作用。本文讨论了血小板5-HT评估的生化动力学方法学问题。
