自闭症和精神分裂症中血小板[3H]丙咪嗪结合情况

Platelet [3H]imipramine binding in autism and schizophrenia.

作者信息

Weizman A, Gonen N, Tyano S, Szekely G A, Rehavi M

出版信息

Psychopharmacology (Berl). 1987;91(1):101-3. doi: 10.1007/BF00690935.

Abstract

[3H]Imipramine binding to platelet membranes was evaluated in ten autistics, eight schizophrenics and seven normal controls. The schizophrenics and eight out of the ten autistics were maintained on chronic neuroleptic treatment. Diagnosis of autism and schizophrenia was established according to the DSM-III criteria. No significant difference in the maximal binding capacity of [3H]imipramine (Bmax) and Kd values could be found among the three groups. It seems that the imipramine binding site is intact both in autism and schizophrenia.

摘要

在10名自闭症患者、8名精神分裂症患者和7名正常对照者中评估了[3H]丙咪嗪与血小板膜的结合情况。8名精神分裂症患者和10名自闭症患者中的8人接受慢性抗精神病药物治疗。根据《精神疾病诊断与统计手册》第三版标准确定自闭症和精神分裂症的诊断。三组之间[3H]丙咪嗪的最大结合容量（Bmax）和平衡解离常数（Kd）值未发现显著差异。看来丙咪嗪结合位点在自闭症和精神分裂症中均保持完整。