Goldman H I
Am J Dis Child. 1980 Jun;134(6):553-5. doi: 10.1001/archpedi.1980.02130180011004.
Twenty-six infants had necrotizing enterocolitis (NEC) in the neonatal unit of the Long Island Jewish-Hillside Medical Center, New Hyde Park, NY, between 1964 and 1976; 25 of these cases occurred between 1973 and 1976. The relationship of feeding practices to this clustering of NEC cases was investigated in two ways: (1) A 10% sample of all admissions, 1964 to 1976, was studied. A striking correlation was found between the yearly incidence of NEC and the percentage of infants in that year who had received large increases in daily feeding volume. The highest mean daily feeding volume occurred in 1974 and 1975, the two years of peak NEC incidence. (2) The feeding records of the 26 NEC cases were studied. Thirteen NEC patients had had large increases in feeding volume within two days of NEC onset. Seven others received greater than 150 mL of formula per kilogram per day prior to NEC onset. Rapid increase in feeding volume and the use of large volumes are suggested as important etiologic factors of NEC.
1964年至1976年间，纽约州新海德公园市长岛犹太山边医疗中心新生儿病房有26名婴儿患坏死性小肠结肠炎（NEC）；其中25例发生在1973年至1976年期间。研究人员从两个方面调查了喂养方式与NEC病例聚集之间的关系：（1）对1964年至1976年所有入院病例的10%样本进行了研究。发现NEC的年发病率与当年每日喂养量大幅增加的婴儿比例之间存在显著相关性。最高的平均每日喂养量出现在1974年和1975年，这两年是NEC发病率的高峰期。（2）研究了26例NEC病例的喂养记录。13例NEC患者在NEC发病前两天内喂养量大幅增加。另外7例在NEC发病前每天每公斤体重接受的配方奶量超过150毫升。喂养量的快速增加和大量使用被认为是NEC的重要病因。
