9-羟基玫瑰树碱：对7,12-二甲基苯并[a]蒽诱导的瑞士小鼠皮肤癌发生的抑制作用。
9-Hydroxyellipticine: inhibitory effect on skin carcinogenesis induced in Swiss mice by 7,12-dimethylbenz[a]anthracene.
作者信息
Lesca P, Mansuy D
出版信息
Chem Biol Interact. 1980 May;30(2):181-7. doi: 10.1016/0009-2797(80)90124-6.
PMID:6771025
Abstract
9-Hydroxyellipticine (9-hydroxy-5,11-dimethyl-6-H-pyrido[4,3b]carbazole), a potent inhibitor of monooxygenases, strongly inhibits the initiation of skin tumors by 7,12-dimethylbenz[a]anthracene (DMBA) in male NMRI Swiss mice. 9-Hydroxyellipticine has not effect on promotion step.
摘要
9-羟基玫瑰树碱（9-羟基-5,11-二甲基-6-H-吡啶并[4,3-b]咔唑）是一种单加氧酶的有效抑制剂，能强烈抑制雄性NMRI瑞士小鼠中由7,12-二甲基苯并[a]蒽（DMBA）引发的皮肤肿瘤。9-羟基玫瑰树碱对促进阶段没有影响。
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