[7,8-苯并黄酮对多环烃诱导的皮肤肿瘤发生率的影响]

[Effect of 7,8-benzoflavone on the incidence of skin tumors induced by polycyclic hydrocarbons].

作者信息

Linnik A B, Kobliakov V A

出版信息

Biull Eksp Biol Med. 1979 May;87(5):454-5.

Abstract

Tumours were induced in CBA mice or (C57BL X CBA)F1 hybrids by the application of benz(a)pyrene (BP), 6-methylBP, 6-formylBP or 7,12-dimethylbenzanthracene (DMBA) to the skin. 7,8-benzoflavone (BF) used in combination with the mentioned agents decreased the carcinogenic action of methyl-substituted hydrocarbons--DMBA and 6-methylBP and had no effect on the carcinogenic action of BP and 6-formylBP. It is suggested that the inhibitory action of BF on carcinogenesis induced by methyl-substituted hydrocarbons was due to the inhibited oxidation of the methyl group.

摘要

通过将苯并(a)芘（BP）、6-甲基BP、6-甲酰基BP或7,12-二甲基苯并蒽（DMBA）涂抹于皮肤，在CBA小鼠或（C57BL×CBA）F1杂交小鼠中诱发肿瘤。与上述试剂联合使用的7,8-苯并黄酮（BF）降低了甲基取代烃类——DMBA和6-甲基BP的致癌作用，而对BP和6-甲酰基BP的致癌作用没有影响。有人认为，BF对甲基取代烃类诱导的致癌作用的抑制作用是由于甲基氧化受到抑制。

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[Effect of 7,8-benzoflavone on the incidence of skin tumors induced by polycyclic hydrocarbons].[7,8-苯并黄酮对多环烃诱导的皮肤肿瘤发生率的影响]

Biull Eksp Biol Med. 1979 May;87(5):454-5.

2

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3

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Carcinog Compr Surv. 1982;7:35-9.

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The effects of antioxidants on skin tumor initiation and aryl hydrocarbon hydroxylase.抗氧化剂对皮肤肿瘤起始及芳烃羟化酶的影响。

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Carcinogenesis. 1986 Jul;7(7):1187-9. doi: 10.1093/carcin/7.7.1187.

8

The effects of benzoflavones on polycyclic hydrocarbon metabolism and skin tumor initiation.苯并黄酮对多环烃代谢及皮肤肿瘤起始的影响。

Chem Biol Interact. 1977 Jun;17(3):297-312. doi: 10.1016/0009-2797(77)90093-x.

9

Effects of ellipticine, flavone, and 7,8-benzoflavone upon 7,12-dimethylbenz[a]anthracene, 7,14-dimethyldibenzo[a,h]anthracene and dibenzo[a,h]anthracene initiated skin tumors in mice.玫瑰树碱、黄酮及7,8-苯并黄酮对7,12-二甲基苯并[a]蒽、7,14-二甲基二苯并[a,h]蒽及二苯并[a,h]蒽引发的小鼠皮肤肿瘤的影响。

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10

[Effect of 7,12-dimethylbenz(alpha)anthracene metabolites on its capacity to induce skin tumors in mice].[7,12-二甲基苯并（α）蒽代谢产物对其诱导小鼠皮肤肿瘤能力的影响]

Vopr Onkol. 1975;21(10):50-5.

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