Linnik A B, Kobliakov V A
Biull Eksp Biol Med. 1979 May;87(5):454-5.
Tumours were induced in CBA mice or (C57BL X CBA)F1 hybrids by the application of benz(a)pyrene (BP), 6-methylBP, 6-formylBP or 7,12-dimethylbenzanthracene (DMBA) to the skin. 7,8-benzoflavone (BF) used in combination with the mentioned agents decreased the carcinogenic action of methyl-substituted hydrocarbons--DMBA and 6-methylBP and had no effect on the carcinogenic action of BP and 6-formylBP. It is suggested that the inhibitory action of BF on carcinogenesis induced by methyl-substituted hydrocarbons was due to the inhibited oxidation of the methyl group.
通过将苯并(a)芘（BP）、6-甲基BP、6-甲酰基BP或7,12-二甲基苯并蒽（DMBA）涂抹于皮肤，在CBA小鼠或（C57BL×CBA）F1杂交小鼠中诱发肿瘤。与上述试剂联合使用的7,8-苯并黄酮（BF）降低了甲基取代烃类——DMBA和6-甲基BP的致癌作用，而对BP和6-甲酰基BP的致癌作用没有影响。有人认为，BF对甲基取代烃类诱导的致癌作用的抑制作用是由于甲基氧化受到抑制。
