Prota G
J Invest Dermatol. 1980 Jul;75(1):122-7. doi: 10.1111/1523-1747.ep12521344.
The color of mammalian hair, skin, and eyes results mainly from the secretory products of melanocytes. These secretory products consist of a wide range of melanin pigments with different structures and compositions. These include black or brown nitrogenous eumelanins; yellow or reddish brown, sulfur-containing pheomelanins, e.g., the trichochromes of low molecular weight; and other pigments whose chemical and physical properties are intermediate between those of typical eumelanins and pheomelanins. Despite the evident differences in molecular size and general properties, all these pigments are biogenetically related, and they arise from a common mmetabolic pathway in which dopaquinone is the key intermediate. The current state of knowledge on the molecular mechanisms governing the etabolic fate of dopaquinone in melanocytes is discussed with special reference to the role of such sulfhydryl compounds as cysteine and glutathione in melanogenesis.
哺乳动物毛发、皮肤和眼睛的颜色主要源于黑素细胞的分泌产物。这些分泌产物由多种结构和组成各异的黑色素组成。其中包括黑色或棕色的含氮真黑素；黄色或红棕色的含硫褐黑素，例如低分子量的三色色素；以及其他化学和物理性质介于典型真黑素和褐黑素之间的色素。尽管这些色素在分子大小和一般性质上存在明显差异，但它们在生物合成上是相关的，并且都来自一个共同的代谢途径，其中多巴醌是关键中间体。本文特别参考半胱氨酸和谷胱甘肽等巯基化合物在黑色素生成中的作用，讨论了黑素细胞中多巴醌代谢命运调控分子机制的当前知识状态。
