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Effect of inhibin-like substance isolated from porcine follicular fluid on the follicle-stimulating hormone (FSH) level in mouse serum and on FSH binding to porcine granulosa cells.

作者信息

Sato E, Ishibashi T, Iritani A

出版信息

Fertil Steril. 1980 Jul;34(1):55-7. doi: 10.1016/s0015-0282(16)44840-5.

DOI:10.1016/s0015-0282(16)44840-5
PMID:6772474
Abstract

An inhibin-like substance, a follicle-stimulating hormone (FSH) inhibitor, was isolated from porcine follicular fluid and purified. Serum FSH levels of unilaterally ovariectomized mice which received injections of the inhibitor were lower than those of unilaterally ovariectomized mice which received injections of saline. The inhibitor also suppressed FSH binding to granulosa cells in vitro. These results suggest that this protein is an FSH inhibitor and that it has two modes of action: suppression of FSH levels in serum and suppression of FSH binding to granulosa cells.

摘要

相似文献

1
Effect of inhibin-like substance isolated from porcine follicular fluid on the follicle-stimulating hormone (FSH) level in mouse serum and on FSH binding to porcine granulosa cells.
Fertil Steril. 1980 Jul;34(1):55-7. doi: 10.1016/s0015-0282(16)44840-5.
2
Purification and action sites of a follicle stimulating hormone inhibitor from bovine follicular fluid.牛卵泡液中促卵泡激素抑制剂的纯化及作用位点
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Inhibition of luteinizing hormone/human chorionic gonadotropin binding to porcine granulosa cells by a follicular fluid protein(s).
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Binding of LH and FSH to porcine granulosa cells during follicular maturation.卵泡成熟过程中促黄体生成素（LH）和促卵泡生成素（FSH）与猪颗粒细胞的结合。
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Evidence for ovarian "inhibin": suppression of the secondary rise in serum follicle stimulating hormone levels in proestrous rats by injection of porcine follicular fluid.卵巢“抑制素”的证据：通过注射猪卵泡液抑制动情前期大鼠血清促卵泡激素水平的二次升高。
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5721-4. doi: 10.1073/pnas.74.12.5721.
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Suppression of serum follicle-stimulating hormone by follicular fluid in the maximally estrogenized, ovariectomized mouse.在雌激素最大化的去卵巢小鼠中，卵泡液对血清促卵泡激素的抑制作用。
Endocrinology. 1978 Nov;103(5):1894-8. doi: 10.1210/endo-103-5-1894.
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Follicle stimulating hormone binding inhibiting activity and inhibin properties of human ovarian cystic and porcine follicular fluid.人卵巢囊肿液和猪卵泡液的促卵泡激素结合抑制活性及抑制素特性
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Effect of porcine follicular fluid on LH and FSH secretion in rats.
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Enhanced stimulation of follicle maturation and ovulatory potential by long acting follicle-stimulating hormone agonists with extended carboxyl-terminal peptides.通过具有延长羧基末端肽的长效促卵泡激素激动剂增强对卵泡成熟和排卵潜能的刺激。
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Differential regulation of inhibin B and inhibin a by follicle-stimulating hormone and local growth factors in human granulosa cells from small antral follicles.促卵泡激素和局部生长因子对人小窦卵泡颗粒细胞中抑制素B和抑制素α的差异调节
J Clin Endocrinol Metab. 2001 Jan;86(1):330-6. doi: 10.1210/jcem.86.1.7107.

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