[正丙酯及其他γ-氨基丁酸能物质在冲突情境中的镇静作用]
[Tranquilizing effect of n-dipropylacetate and other GABA-ergic substances in conflict situations].
作者信息
Kharlamov A N, Raevskiĭ K S
出版信息
Biull Eksp Biol Med. 1980 Jul;89(7):35-7.
PMID:6773597
Abstract
Effect of n-dipropyl acetate (n-DPA), amino oxyacetic acid (AOAA), pantogam and piracetam on rat behaviour was studied under conflict situation. n-DPA, AOAA and piracetam increased significantly the main index of the tranquilizing action, that is the number of water intakes from the drinking bowl, supported by electric stimulation. This effect was most pronounced in n-DPA. Bicuculline and corasol almost completely eliminated the tranquilizing effect of n-DPA, while this effect was abolished by caffeine only by 50%.
摘要
在冲突情境下研究了乙酸正丙酯（n-DPA）、氨氧基乙酸（AOAA）、泛硫乙胺和吡拉西坦对大鼠行为的影响。n-DPA、AOAA和吡拉西坦显著提高了镇静作用的主要指标，即在电刺激支持下从饮水碗饮水的次数。这种作用在n-DPA中最为明显。荷包牡丹碱和可拉佐几乎完全消除了n-DPA的镇静作用，而咖啡因仅使该作用减弱50%。
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