大鼠体内的鼠类圆线虫感染。II. 可的松治疗的效果。
Strongyloides ratti infections in rats. II. Effects of cortisone treatment.
作者信息
Olson C E, Schiller E L
出版信息
Am J Trop Med Hyg. 1978 May;27(3):527-31. doi: 10.4269/ajtmh.1978.27.527.
PMID:677363
Abstract
Cortisone (5 mg daily subcutaneously) suppressed both primary and secondary immune explusion of Strongyloides ratti, and reduced the intestinal mast cell response, but did not induce hyperinfection in rats. Cortisone-treated animals expelled primary worm burdens without complication about 2 wk after steroid treatment. A model for gastrointestinal hypersensitivity syndromes in discussed.
摘要
可的松（每日5毫克皮下注射）抑制了大鼠类圆线虫的初次和二次免疫排出，并降低了肠道肥大细胞反应，但未在大鼠中诱发重度感染。经可的松治疗的动物在类固醇治疗后约2周排出了初次感染的虫负荷且无并发症。文中讨论了一种胃肠道过敏综合征模型。
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