Berger R, Bernheim A, Flandrin G
C R Seances Acad Sci D. 1980 Jun 30;290(24):1557-9.
The absence of chromosome abnormalities in 50% of human acute leukemias stress the significance of cytogenetic abnormalities in malignancies. Karyotypically normal cells from acute leukemias were shown to be non leukemic cells by cytological and cytogenetic comparisons. Chromosomally normal acute promyelocytic leukemias could be explained by differences between proliferation rates of bone marrow cells and by bias when choosing metaphases to be analysed. The role of chromosomal abnormalities in acute leukemia must be therefore questioned from a new definition of cytogenetic methods.
50%的人类急性白血病不存在染色体异常，这凸显了细胞遗传学异常在恶性肿瘤中的重要性。通过细胞学和细胞遗传学比较表明，急性白血病中核型正常的细胞是非白血病细胞。染色体正常的急性早幼粒细胞白血病可以通过骨髓细胞增殖率的差异以及选择分析中期时的偏差来解释。因此，必须从细胞遗传学方法的新定义来质疑染色体异常在急性白血病中的作用。
