Szwed J J, Melman A
Invest Urol. 1980 Jul;18(1):21-3.
The object of this study was to determine the effect of mannitol upon lymph flow during acute unilateral renal obstruction in the dog--whether it would sustain, increase, or have an adverse effect upon renal hilar lymph flow. Two groups of dogs were used so that the efficacy of bolus injection could be compared with continuous infusion of mannitol. After ureteral obstruction renal hilar lymph flow increased significantly. Renal artery pressure, venous pressure, blood flow, and lymph flow were sustained by both bolus and continuous infusion. These results show that intravenous mannitol given during acute ureteral obstruction will sustain an increase in renal hilar lymph flow.
本研究的目的是确定甘露醇对犬急性单侧肾梗阻期间淋巴液流动的影响——它是会维持、增加还是对肾门淋巴液流动产生不利影响。使用了两组犬，以便将推注给药的效果与甘露醇持续输注的效果进行比较。输尿管梗阻后，肾门淋巴液流动显著增加。推注和持续输注均能维持肾动脉压、静脉压、血流量和淋巴液流动。这些结果表明，在急性输尿管梗阻期间静脉注射甘露醇将维持肾门淋巴液流动的增加。
