Lux G D, Marton L J, Baylin S B
Science. 1980 Oct 10;210(4466):195-8. doi: 10.1126/science.6774420.
A transient increase in ornithine decarboxylase activity and polyamine biosynthesis occurs in the intestinal mucosa of the newborn rat in the third week after birth. During this period, there is a rapid conversion of the mucosa from a fetal to a mature adult status. A similar increase in ornithine decarboxylase activity also accompanies the rapid recovery of the mucosa 1 week after an injury is induced by chemotherapy in adult rats. In vivo, alpha-difluoromethyl ornithine, a highly selective, enzyme-activated, irreversible inhibitor, suppresses these increases in mucosal ornithine decarboxylase and delays both intestinal mucosal maturation and recovery from injury. Thus increased ornithine decarboxylase activity, with the resultant increase in polyamine content, may play an essential role in intestinal mucosal maturation and regeneration in the rat.
出生后第三周，新生大鼠肠黏膜中鸟氨酸脱羧酶活性和多胺生物合成出现短暂增加。在此期间，黏膜迅速从胎儿状态转变为成熟的成年状态。成年大鼠化疗诱导损伤后1周，黏膜快速恢复时也伴随鸟氨酸脱羧酶活性的类似增加。在体内，α-二氟甲基鸟氨酸是一种高度选择性、酶激活的不可逆抑制剂，可抑制黏膜鸟氨酸脱羧酶的这些增加，并延迟肠黏膜成熟和损伤恢复。因此，鸟氨酸脱羧酶活性增加以及随之而来的多胺含量增加，可能在大鼠肠黏膜成熟和再生中起重要作用。
