二胺氧化酶和鸟氨酸脱羧酶与快速增殖上皮中成熟细胞的关联。

Association of diamine oxidase and ornithine decarboxylase with maturing cells in rapidly proliferating epithelium.

作者信息

Baylin S B, Stevens S A, Shakir K M

出版信息

Biochim Biophys Acta. 1978 Jul 3;541(3):415-9. doi: 10.1016/0304-4165(78)90200-3.

Abstract

Diamine oxidase and ornithine decarboxylase activities are shown to have a parallel distribution across rat small intestine mucosa; levels of both enzyme activities are sharply higher in mature cells in the villus tip region than in proliferating cells in the crypt areas. Histidine decarboxylase levels were not measurable in the same cell preparations and aromatic-L-amino-acid decarboxylase activity was distributed in an opposite pattern to diamine oxidase and ornithine decarboxylase. The results suggest that intestinal diamine oxidase could be involved with polyamine metabolism. The new findings for ornithine decarboxylase suggest an in vivo role for polyamines in non-proliferative cells; rat small intestinal mucosa may be an excellent model for investigating the function of polyamines in regenerating cells.

摘要

已表明二胺氧化酶和鸟氨酸脱羧酶活性在大鼠小肠黏膜中呈平行分布；绒毛顶端区域成熟细胞中的这两种酶活性水平明显高于隐窝区域增殖细胞中的水平。在相同细胞制剂中未检测到组氨酸脱羧酶水平，且芳香族-L-氨基酸脱羧酶活性的分布模式与二胺氧化酶和鸟氨酸脱羧酶相反。结果表明，肠道二胺氧化酶可能参与多胺代谢。鸟氨酸脱羧酶的新发现提示多胺在非增殖细胞中具有体内作用；大鼠小肠黏膜可能是研究多胺在再生细胞中功能的理想模型。