铜绿假单胞菌菌体成分对实验性小鼠烧伤感染保护性免疫的影响
Effects of somatic component of Pseudomonas aeruginosa on protective immunity in experimental mouse burn infection.
作者信息
Okada K, Kawaharajo K, Kasai T, Homma J Y
出版信息
Jpn J Exp Med. 1980 Feb;50(1):53-61.
In the mouse burn model of Stieritz and Holder [19], a three-component vaccine consisting of elastase toxoid, protease toxoid and the common antigen (OEP) of P. aeruginosa was found significantly effective on protection against subcutaneous injection with strain IFO 3455, but not with strains M2 or PF 2243. Investigating the differences, it was clarified that somatic antigens of strains M2 and PF 2243 did not contain serological antigens cross-reacting with OEP. Accordingly, the protective effects of the somatic antigen of strains M2 were investigated with the result that both formalin and heat-killed antigens demonstrated significant protection against challenge with strain M2 in the mouse burn model. As strains PF 2243 and M2 were found to belong to the same serotype 16 of Homma's schema [23], it is presumed that somatic antigens of serotype 16 are devoid of OEP. At the same time, it is suggested that the somatic component of P. aeruginosa is essential to the effects of the multi-component vaccines on protective immunity.
在施蒂里茨和霍尔德[19]的小鼠烧伤模型中，发现由弹性蛋白酶类毒素、蛋白酶类毒素和铜绿假单胞菌共同抗原（OEP）组成的三联疫苗，对预防皮下注射IFO 3455菌株有效，但对M2或PF 2243菌株无效。通过研究差异发现，M2和PF 2243菌株的菌体抗原不含与OEP发生交叉反应的血清学抗原。因此，研究了M2菌株菌体抗原的保护作用，结果表明，在小鼠烧伤模型中，福尔马林灭活抗原和热灭活抗原对抵抗M2菌株攻击均显示出显著的保护作用。由于发现PF 2243和M2菌株属于本间分类法[23]中的同一血清型16，推测血清型16的菌体抗原不含OEP。同时表明，铜绿假单胞菌的菌体成分对于多组分疫苗的保护性免疫作用至关重要。
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