Baker E L, Landrigan P J, Glueck C J, Zack M M, Liddle J A, Burse V W, Housworth W J, Needham L L
Am J Epidemiol. 1980 Oct;112(4):553-63. doi: 10.1093/oxfordjournals.aje.a113024.
Polychlorinated biphenyls (PCB) were discovered in sewage sludge used for fertilizer in Bloomington, Indiana. The PCB had been discharged into the municipal sewage system by an electrical capacitor manufacturing plant. To study the epidemiology and metabolic consequences of PCB exposure an epidemiologic and clinical survey was conducted. Mean serum PCB levels were 17.4 ppb in 89 sludge users, 75.1 ppb in 18 workers with occupational exposure to PCB, 33.6 ppb in 19 members of those workers' families, and 24.4 ppb in 22 community residents without unusual exposure to PCB. In sludge users PCB levels were associated positively with per cent performance of garden care (p = 0.035) and negatively with wearing gloves while gardening (p = 0.021), but were not significantly associated with the amount of sludge used or the duration of exposure. In no groups were chloracne or systemic symptoms of PCB toxicity noted, nor were significant correlations found between PCB levels and tests of hematologic, hepatic, or renal function. Plasma triglyceride levels increased significantly with serum PCB concentrations in both alcohol drinkers and nondrinkers (r = 0.541, n = 36, p < 0.001 for nondrinkers). These data indicate that PCB may alter lipid metabolism at levels of exposure and bioaccumulation insufficient to produce overt symptoms.
在印第安纳州布卢明顿市，人们发现用于肥料的污水污泥中含有多氯联苯（PCB）。这些多氯联苯是由一家电容器制造工厂排放到城市污水系统中的。为了研究多氯联苯暴露的流行病学和代谢后果，开展了一项流行病学和临床调查。89名污泥使用者的血清多氯联苯平均水平为17.4 ppb，18名职业性接触多氯联苯的工人为75.1 ppb，这些工人家庭中的19名成员为33.6 ppb，22名未接触过异常多氯联苯的社区居民为24.4 ppb。在污泥使用者中，多氯联苯水平与园艺护理的完成百分比呈正相关（p = 0.035），与园艺时戴手套呈负相关（p = 0.021），但与污泥使用量或接触持续时间无显著关联。在所有组中均未发现氯痤疮或多氯联苯中毒的全身症状，多氯联苯水平与血液学、肝脏或肾脏功能测试之间也未发现显著相关性。在饮酒者和非饮酒者中，血浆甘油三酯水平均随血清多氯联苯浓度显著升高（非饮酒者r = 0.541，n = 36，p < 0.001）。这些数据表明，在暴露和生物累积水平不足以产生明显症状的情况下，多氯联苯可能会改变脂质代谢。
