Pothu Usha Kiran, Thammisetty Anil Kumar, Nelakuditi Lakshmana Kumar
Department of Biochemistry, GSL Medical College and General Hospital, Rajahmundry, Andhra Pradesh, India.
J Family Med Prim Care. 2019 Jun;8(6):2073-2078. doi: 10.4103/jfmpc.jfmpc_239_19.
Agriculture being the predominant occupation in India with rampant usage of pesticides to meet its enormous population needs. This pesticide abuse is taking a toll on the health of the persons involved in this work.
To evaluate pesticide exposure by assessing serum cholinesterase levels, and comparing them with the serum lipid profile levels which assumes the cardiovascular risk status.
It is a cross-sectional comparative study involving around 283 agricultural farm workers in Rajamahendravaram, Andhra Pradesh. The study period was for about 3 months during pesticide spraying season.
All the blood samples were collected and analysed for biochemical parameters like plasma glucose, blood urea, serum creatinine, and lipid profile and serum cholinesterase levels using XL 640 fully automated random access analyser.
Results were analysed using SPSS software version 20.
The study group was classified into two groups based on serum cholinesterase levels. It was observed that there were significant alterations in lipid profile levels in the study group with decreased cholinesterase levels when compared to those of normal cholinesterase levels. There was significant negative correlation between cholinesterase levels and non-HDL cholesterol and total cholesterol/HDL ratio.
This study implicates that the pesticides have an adverse health effect with regard to cardiovascular risk status.
农业是印度的主要职业，为满足庞大人口的需求而大量使用农药。这种农药滥用正在对从事这项工作的人员的健康造成损害。
通过评估血清胆碱酯酶水平来评估农药暴露情况，并将其与反映心血管风险状况的血脂谱水平进行比较。
这是一项横断面比较研究，涉及安得拉邦拉贾马亨德拉瓦拉姆的约283名农业农场工人。研究期间为农药喷洒季节的约3个月。
采集所有血样，使用XL 640全自动随机存取分析仪分析血浆葡萄糖、血尿素、血清肌酐、血脂谱和血清胆碱酯酶水平等生化参数。
使用SPSS软件20版对结果进行分析。
根据血清胆碱酯酶水平将研究组分为两组。观察到与正常胆碱酯酶水平组相比，研究组中胆碱酯酶水平降低时血脂谱水平有显著变化。胆碱酯酶水平与非高密度脂蛋白胆固醇和总胆固醇/高密度脂蛋白比值之间存在显著负相关。
本研究表明，农药对心血管风险状况有不良健康影响。
