Hosokawa S, Iguchi T, Caveness W F, Kato M, O'Neill R R, Wakisaka S, Malamut B L
Ann Neurol. 1980 Mar;7(3):222-9, 236-7. doi: 10.1002/ana.410070305.
During focal motor seizures induced by injecting penicillin into the face-hand area of the right motor cortex of 24-month-old monkeys, the sensorimotor system was manipulated by three methods. Elimination, by a paralytic agent, of proprioceptive input from contracting muscles and joints did not alter the electrographic expression of the seizure or the pattern of local glucose utilization in cortical or subcortical components of the sensorimotor system. An overall increase in the rate of energy metabolism occurred in the paralyzed monkeys with electrographic seizures. Cryogenic destruction of up to 90% of the ipsilateral ventral caudal globus pallidus had no effect on electrographic or clinical expression of the seizure. Electrical stimulation of the ipsilateral ventral caudal globus pallidus caused reproducible maximum expression of electrographic and clinical seizure phenomena for the 90-second duration of the stimulus.
在对24个月大的猴子右侧运动皮层的面-手区域注射青霉素诱发局灶性运动性癫痫发作期间，通过三种方法对感觉运动系统进行了操控。使用麻痹剂消除收缩肌肉和关节的本体感觉输入，并未改变癫痫发作的电图表现或感觉运动系统皮质或皮质下成分中的局部葡萄糖利用模式。出现电图癫痫发作的麻痹猴子的能量代谢率总体上升。同侧腹侧尾状苍白球高达90%的低温损毁对癫痫发作的电图或临床表现没有影响。对同侧腹侧尾状苍白球进行电刺激，在90秒的刺激持续时间内可引起可重复的癫痫电图和临床发作现象的最大表现。
