Delgado-Zygmunt T, Arbab M A, Shiokawa Y, Svendgaard N A
Neurosurgical Research Department, University Hospital, Lund, Sweden.
Acta Neurochir (Wien). 1993;121(3-4):166-73. doi: 10.1007/BF01809270.
A double-isotope autoradiography technique was used to evaluate cerebral blood flow (CBF) and cerebral glucose metabolism (CMRglu) during the late phase of vasospasm in a squirrel monkey subarachnoid haemorrhage (SAH) model. Cisternal blood injections induced both global and focal changes in CBF and CMRglu six days following SAH, the timepoint of maximal late spasm in this model. There was a global decrease in CBF of about 30% accompanied by an increase in deoxyglucose uptake of about 50%. Four of seven animals also had foci with flow decreased to 40% of control and deoxyglucose uptake increased to 300% of control. There was an altered but still present interdependence between flow and metabolism post SAH.
采用双同位素放射自显影技术，在松鼠猴蛛网膜下腔出血（SAH）模型中评估血管痉挛后期的脑血流量（CBF）和脑葡萄糖代谢（CMRglu）。在SAH后6天，即该模型中最大晚期痉挛的时间点，脑池内注射血液引起了CBF和CMRglu的整体和局部变化。CBF整体下降约30%，同时脱氧葡萄糖摄取增加约50%。7只动物中有4只还出现了血流降至对照的40%且脱氧葡萄糖摄取增加至对照的300%的病灶。SAH后血流与代谢之间的相互依存关系虽有改变但仍然存在。
