Barclay G R, Greiss M A, Urbaniak S J
Br Med J. 1980 Jun 28;280(6231):1569-71. doi: 10.1136/bmj.280.6231.1569.
Intensive plasma exchange was used to reduce the maternal anti-D concentration in case of severe rhesus haemolytic disease. Initially the concentration fell from 30 to 4 IU/ml, but after six exchanges it increased to 490 IU/ml despite continued exchanges, and intrauterine fetal death eventually ensued. The increase in the rate of maternal anti-D production coincided with, and may have resulted from, removal of plasma immuno-regulatory factors that inhibited in-vitro lymphocyte functions. These results that the role of plasma exchange in haemolytic disease of the newborn is more complex than simply removing the antibody and that further investigations are needed.
对于严重的恒河猴溶血病病例，采用强化血浆置换来降低母体抗-D浓度。最初，浓度从30降至4 IU/ml，但经过六次置换后，尽管继续进行置换，其浓度仍升至490 IU/ml，最终导致宫内胎儿死亡。母体抗-D产生速率的增加与抑制体外淋巴细胞功能的血浆免疫调节因子的去除同时发生，并且可能是由其导致的。这些结果表明，血浆置换在新生儿溶血病中的作用比单纯去除抗体更为复杂，需要进一步研究。
