Ijaiya K
Eur J Pediatr. 1980 Sep;134(3):231-7. doi: 10.1007/BF00441478.
Metoclopramide (MCP), a derivative of procainamide was compared with exercise, arginine, insulin and thyrotropin releasing hormone (TRH) as a prolactin (PRL) releaser in children. The peak response of plasma PRL after oral administration of MCP was greater than that after strenuous exercise and after i.v. administration of pharmacodynamic agents. Normal PRL and TSH responses were observed after TRH administration in all subjects. Variable PRL responses were seen after exercise and after i.v. administration of arginine and insulin, despite significant growth hormone (GH) release following the administration of these agents. MCP produced no increase in plasma TSH. Metoclopramide may be useful for dynamic testing of PRL release in children. It can be taken orally and is free of side-effects.
甲氧氯普胺（MCP）是普鲁卡因胺的衍生物，在儿童中作为催乳素（PRL）释放剂，与运动、精氨酸、胰岛素及促甲状腺激素释放激素（TRH）进行了比较。口服MCP后血浆PRL的峰值反应大于剧烈运动后及静脉注射药效学药物后的反应。所有受试者在注射TRH后均观察到正常的PRL和TSH反应。运动后以及静脉注射精氨酸和胰岛素后，尽管这些药物注射后有显著的生长激素（GH）释放，但PRL反应各不相同。MCP未使血浆TSH升高。甲氧氯普胺可能有助于儿童PRL释放的动态检测。它可以口服且无副作用。
