Ijaiya K, Roth B, Schwenk A
Clin Endocrinol (Oxf). 1980 Jun;12(6):589-94. doi: 10.1111/j.1365-2265.1980.tb01380.x.
The growth hormone (GH) and prolactin (PRL) responses to metoclopramide (MCP) were compared to those with arginine and insulin-induced hypoglycaemia in eight children. While a significant rise in GH release after stimulation with arginine and insulin occurred in all subjects (P less than 0.05), no significant increase after MCP ingestion was observed. Metoclopramide, a dopamine antagonist, stimulated PRL release in all children, while arginine and insulin-induced hypoglycaemia stimulation tests showed variable PRL responses. A statistically significant increase in cortisol secretion 5 h following MCP was observed (trend test, Cox & Stuart, 1955) (P less than 0.05), but the plasma concentration at this time was still within the normal range. Metoclopramide stimulation is not a suitable test for growth hormone deficiency in children.
对8名儿童使用甲氧氯普胺（MCP）后生长激素（GH）和催乳素（PRL）的反应，与使用精氨酸和胰岛素诱发低血糖后的反应进行了比较。虽然所有受试者在用精氨酸和胰岛素刺激后GH释放均显著升高（P<0.05），但摄入MCP后未观察到显著增加。甲氧氯普胺是一种多巴胺拮抗剂，可刺激所有儿童的PRL释放，而精氨酸和胰岛素诱发低血糖刺激试验显示PRL反应各不相同。观察到MCP给药5小时后皮质醇分泌有统计学意义的增加（趋势检验，Cox & Stuart，1955年）（P<0.05），但此时血浆浓度仍在正常范围内。甲氧氯普胺刺激试验不适用于儿童生长激素缺乏症的检测。
