Stenman G, Heyden G
J Oral Pathol. 1980 May;9(3):155-62. doi: 10.1111/j.1600-0714.1980.tb00372.x.
Biopsy specimens were repeatedly excised from 10 patients with minor and major recurrent aphthous ulcers (RAS). All lesions represented premonitory stages of RAS. The histological and enzyme histochemical investigations were indicative of an early degeneration of individual, suprabasal epithelial cells. The metabolically negative, vacuolated cells were surrounded by cells with normal enzyme activity. No inflammatory reactions were recorded in the connective tissue at this stage. At more advanced stages of the disease the distribution of vacuolated cells within the oral epithelium increased and at the same time an inflammatory reaction in the connective tissue appeared. The vacuolated cells seemed to coalesce and form minor, intraepithelial vesicles. The findings of early intraepithelial degeneration of individual cells in stratum spinosum are compatible with both a viral and an immunological etiology of RAS.
从10例患有轻度和重度复发性阿弗他溃疡（RAS）的患者身上反复切除活检标本。所有病变均代表RAS的先兆阶段。组织学和酶组织化学研究表明，个别基底上层上皮细胞出现早期变性。代谢呈阴性的空泡化细胞被酶活性正常的细胞所包围。在此阶段，结缔组织中未记录到炎症反应。在疾病的更晚期，口腔上皮内空泡化细胞的分布增加，同时结缔组织中出现炎症反应。空泡化细胞似乎融合并形成微小的上皮内水疱。棘层中个别细胞的早期上皮内变性结果与RAS的病毒病因和免疫病因均相符。
