复发性阿弗他溃疡中的抗体依赖性细胞毒性作用
Antibody-dependent cellular cytotoxicity in recurrent aphthous ulceration.
作者信息
Greenspan J S, Gadol N, Olson J A, Talal N
出版信息
Clin Exp Immunol. 1981 Jun;44(3):603-10.
Antibody-dependent cellular cytotoxicity (ADCC) was investigated as s possible mechanism of pathogenesis in recurrent aphthous ulceration (RAU). ADCC induced by mononuclear cells from patients at various stages of RAU was compared with ADCC induced by mononuclear cells from paired controls. Chicken red blood cells (ChRBC) coated with rabbit anti-ChRBC antibody were used as targets. A significant increase in ADCC (P less than 0.01, paired sample t-test) in patients' samples as compared with controls was found only at the early stage of the disease. No increased cytotoxicity over control values was observed at any other single stage of the disease. The transient increased cytotoxicity observed in the early stage of RAU may reflect a number of possible mechanisms, including an increased number of ADCC effector cells only at the early stage, an increase in Fc receptor avidity, or an increase in efficiency of the existing effector cell population.
抗体依赖性细胞毒性（ADCC）作为复发性阿弗他溃疡（RAU）发病机制的一种可能机制进行了研究。将RAU不同阶段患者的单核细胞诱导的ADCC与配对对照的单核细胞诱导的ADCC进行比较。用兔抗鸡红细胞（ChRBC）抗体包被的鸡红细胞作为靶细胞。仅在疾病早期发现患者样本中的ADCC显著增加（P<0.01，配对样本t检验），与对照组相比。在疾病的任何其他单一阶段均未观察到细胞毒性超过对照值。在RAU早期观察到的细胞毒性短暂增加可能反映了多种可能机制，包括仅在早期ADCC效应细胞数量增加、Fc受体亲和力增加或现有效应细胞群体效率提高。
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