从小鼠免疫球蛋白分泌型μ链信使核糖核酸的克隆互补脱氧核糖核酸确定的3'末端序列。
The sequence at the 3' terminus of mouse immunoglobulin secreted mu chain messenger RNA determined from cloned cDNA.
作者信息
Matthyssens G, Rabbitts T H
出版信息
Nucleic Acids Res. 1980 Feb 25;8(4):703-13.
Abstract
The 3' terminal nucleotide sequence of two clones containing DNA complementary to mu chain mRNA of IgM-secreting cells has been determined. The sequence shows a termination codon (UGA) adjacent to the terminal tyrosine codon for the secreted protein and a 3' non-coding region of at least 106 bases. The primary translation product of this mu chain mRNA seems to terminate at the tyrosine of the secreted protein.
摘要
已确定了两个克隆的3'末端核苷酸序列，这些克隆含有与分泌IgM细胞的μ链mRNA互补的DNA。该序列显示，在分泌蛋白的末端酪氨酸密码子附近有一个终止密码子（UGA），以及一个至少106个碱基的3'非编码区。这种μ链mRNA的初级翻译产物似乎在分泌蛋白的酪氨酸处终止。
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