用苯巴比妥、吲哚美辛、双氯芬酸钠和四氯化碳预处理大鼠对1-(2-四氢呋喃基)-5-氟尿嘧啶药效学的影响。
Altered pharmacodynamics of 1-(2-tetrahydrofuryl)-5-fluorouracil by pretreatment of rats with phenobarbital, indomethacin, diclofenac sodium and carbon tetrachloride.
作者信息
Hobara N, Watanabe A
出版信息
Pharmacology. 1980;21(5):323-6. doi: 10.1159/000137447.
The disappearance curves of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) from the circulating blood were divided into three different phases, K1, K2 and K3 after its intravenous administration to rats. The relationship between the activity of liver microsomal drug-metabolizing enzymes and K3 values, which were obtained by measuring FT-207 levels between 5 and 24 h after the injection, was observed with phenobarbital, indomethacin, diclofenac sodium and carbon tetrachloride-pretreated rats. Therefore, the blood disappearance rate of K3 was suggested to be an effective parameter for estimating FT-207 metabolism in the liver.
将1-(2-四氢呋喃基)-5-氟尿嘧啶（FT-207）静脉注射给大鼠后，其在循环血液中的消失曲线分为K1、K2和K3三个不同阶段。通过对苯巴比妥、吲哚美辛、双氯芬酸钠和四氯化碳预处理的大鼠进行观察，研究了肝微粒体药物代谢酶活性与注射后5至24小时之间通过测量FT-207水平获得的K3值之间的关系。因此，K3的血液消失率被认为是评估肝脏中FT-207代谢的有效参数。
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