Matthews A W
Q J Med. 1977 Apr;46(182):179-95.
A technique has been developed which enables respiratory motor output to be measured independently of lung mechanics. The maximum rate of change of pressure at the mouth during initial transient occlusion of the airway, (d P/dt) max., represents the rate of isometric force development by the inspiratory muscles. This technique was used to study central CO2 sensitivity in 40 patients with chronic airways obstruction. Subnormal CO2 sensitivity was associated with chronic cough and sputum production, relatively mild dyspnoea, raised arterial CO2 tension, hypoxaemia, polycythaemia and cor pulmonale. Normal CO2 sensitivity was associated with severe dyspnoea, normal blood gas tensions, and allergic features.
已开发出一种技术，可独立于肺力学来测量呼吸运动输出。气道初始短暂阻塞期间口腔压力的最大变化率（dP/dt）max.代表吸气肌等长力量发展的速率。该技术用于研究40例慢性气道阻塞患者的中枢二氧化碳敏感性。二氧化碳敏感性低于正常与慢性咳嗽、咳痰、相对轻度的呼吸困难、动脉血二氧化碳分压升高、低氧血症、红细胞增多症和肺心病有关。正常的二氧化碳敏感性与严重呼吸困难、正常血气张力和过敏特征有关。
