Barrett T V, Hoff R H, Mott K E, Miles M A, Godfrey D G, Teixeira R, Almeida de Souza J A, Sherlock I A
Trans R Soc Trop Med Hyg. 1980;74(1):84-90. doi: 10.1016/0035-9203(80)90016-4.
Culture forms of 104 stocks of Trypanosoma cruzi isolated in different regions of the State of Bahia were compared by electrophoresis of six enzymes. The three distinct combinations of isoenzyme patterns seen were designated ZI, Z2 and Z3. In an area of endemic Chagas's disease in eastern Bahia, T. cruzi Z1 was associated with sylvatic mammals and sylvatic triatomines, whereas T. cruzi Z2 was associated with a separate domestic cycleof transmission. T. cruzi Z1 was also found in sylvatic triatomines from other parts of the State. In contrast, in an area of the São Francisco Valley region of western Bahia, both T. cruzi Z1 and Z2 were isolated from man, domestic animals, and peridomestic rats. T. cruzi Z3 was isolated from an armadillo and from Panstrongylus geniculatus, a triatomine commonly found in armadillo burrows. Both T. cruzi Z1 and Z2 appeared to be pathogenic in man: T. cruzi Z1 was isolated from patients with acute Chagas's disease and from a single patient with chronic cardiac manifestations. T. cruzi Z2 was isolated from some asymptomatic individuals but was also associated with acute disease and chronic cardiac and digestive syndromes.
通过对六种酶进行电泳，比较了在巴伊亚州不同地区分离出的104株克氏锥虫的培养形式。观察到的三种不同的同工酶模式组合分别被命名为ZI、Z2和Z3。在巴伊亚州东部的恰加斯病流行区，克氏锥虫Z1与野生哺乳动物和野生锥蝽有关，而克氏锥虫Z2与一个独立的家庭传播循环有关。克氏锥虫Z1也在该州其他地区的野生锥蝽中被发现。相比之下，在巴伊亚州西部的圣弗朗西斯科谷地区，克氏锥虫Z1和Z2都从人、家畜和家栖鼠类中分离出来。克氏锥虫Z3是从一只犰狳和从犰狳洞穴中常见的一种锥蝽——膝状泛锥蝽中分离出来的。克氏锥虫Z1和Z2似乎对人都有致病性：克氏锥虫Z1是从患有急性恰加斯病的患者以及一名患有慢性心脏表现的患者中分离出来的。克氏锥虫Z2是从一些无症状个体中分离出来的，但也与急性疾病以及慢性心脏和消化系统综合征有关。
