冻干的凝血因子VIII浓缩物中的血管性血友病因子（VIII/vWF）

Von Willebrand Factor (VIIIVWF) in lyophilized Factor VIII concentrates.

作者信息

McCue M J, Brossoit A D, Marmer D J, Head D R

出版信息

Am J Hematol. 1980;9(1):39-42. doi: 10.1002/ajh.2830090105.

Abstract

Several (14) commercially prepared, lyophilized Factor VIII concentrates were assayed for VIIIAHF, VIIIAg, and VIIIVWF. Significant levels of VIIIAg (immunologic) and VIIIVWF (von Willebrand Factor) were present in addition to VIIIAHF (Functional VIII, Antihemophilic Factor, Factor VIII coagulant activity). An average of 0.95 units of VIIIVWF (range 0.47--1.7) were present for every 1.0 unit of VIIIAHF (as stated on the manufacturer's label). We suggest that the various lyophilized preparations of Factor VIII concentrate available could be assayed for VIIIVWF and should be tested therapeutically in patients with von Willebrand disease.

摘要

对几种（14种）市售冻干凝血因子VIII浓缩剂进行了抗血友病因子VIII（VIIIAHF）、VIII因子相关抗原（VIIIAg）和血管性血友病因子（VIIIVWF）检测。除了VIIIAHF（功能性VIII因子、抗血友病因子、凝血因子VIII凝血活性）外，还存在显著水平的VIIIAg（免疫学）和VIIIVWF（血管性血友病因子）。每1.0单位VIIIAHF（如制造商标签所示）平均含有0.95单位VIIIVWF（范围为0.47 - 1.7）。我们建议，可对现有的各种冻干凝血因子VIII浓缩剂进行VIIIVWF检测，并应对血管性血友病患者进行治疗性测试。