恶性疾病治疗对儿童生长发育的影响。
Effect of treatment of malignant disease on growth in children.
作者信息
Griffin N K, Wadsworth J
出版信息
Arch Dis Child. 1980 Aug;55(8):600-3. doi: 10.1136/adc.55.8.600.
Abstract
The growth of 95 children with malignant disease was studied over a 3- or 4-year period, and compared with the growth of normal children matched for age and sex by calculation of the standard deviation score. The mean standard deviation score of the children with leukaemia fell in the first year of treatment, and thereafter showed little change, remaining below the normal. This effect was related to cranial and craniospinal irradiation, but not to age or duration of chemotherapy. The loss in eventual height attained was small and does not suggest any long-term interference with growth hormone production.
摘要
对95名患有恶性疾病的儿童进行了为期3或4年的生长情况研究，并通过计算标准差得分，与年龄和性别匹配的正常儿童的生长情况进行比较。白血病患儿的平均标准差得分在治疗的第一年下降，此后变化不大，仍低于正常水平。这种影响与颅脑和全脊髓照射有关，但与年龄或化疗持续时间无关。最终身高的损失很小，并不表明对生长激素分泌有任何长期干扰。
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