Yamaoka K, Nomura T, Iriyama K, Kojima S
Bio-Science Department Komae Branch, Abiko Research Laboratory, Tokyo, Japan.
Physiol Chem Phys Med NMR. 1998;30(1):15-23.
Blood activities of hepatocellular enzymes such as lactate dehydrogenase (LDH), glutamic pyruvic transaminase (GPT) and glutamic oxalacetic transaminase (GOT) peaked at 12 hours after a single intraabdominal injection of ferric nitrilotriacetate (Fe(3+)-NTA) in rats. Enzymes such as alkaline phosphatase (ALP) and leucin amino peptidase (LAP) originating in the capillary bile ducts or bile secretory liver cells were also released into the blood between 6-24 hours after intraabdominal injection of Fe(3+)-NTA in rats. Furthermore, hyperoxidation of lipids occurred in rat hepatic cell membranes, reaching a peak 6 hours after intraabdominal injection of Fe(3+)-NTA. It was found that a single prior 0.5 Gy whole body X-ray irradiation significantly increased superoxide dismutase (SOD) activities and suppressed above-mentioned symptoms of transient hepatopathy in rats.
在大鼠腹腔内单次注射次氮基三乙酸铁（Fe(3+)-NTA）后，肝细胞酶如乳酸脱氢酶（LDH）、谷丙转氨酶（GPT）和谷草转氨酶（GOT）的血液活性在12小时达到峰值。源自胆小管或胆汁分泌肝细胞的碱性磷酸酶（ALP）和亮氨酸氨基肽酶（LAP）等酶，在大鼠腹腔内注射Fe(3+)-NTA后6至24小时也释放入血。此外，大鼠肝细胞膜发生脂质过氧化，在腹腔内注射Fe(3+)-NTA后6小时达到峰值。研究发现，预先单次全身0.5 Gy X射线照射可显著提高超氧化物歧化酶（SOD）活性，并抑制大鼠上述短暂性肝病症状。
