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[延迟电刺激小鼠内嗅皮层诱导的记忆促进作用]

[Memory facilitation induced by delayed electric stimulation of the entorhinal cortex in mice].

作者信息

Gauthier M, Soumireu-Mourat B, Destrade C

出版信息

C R Seances Acad Sci D. 1980 Oct 6;291(5):505-7.

PMID:6777067
Abstract

A subconvulsive bilateral stimulation of the lateral entorhinal cortex has been applied in BALB/c mice at different time intervals after an appetitive operant conditioning task. 24 hrs later, compared to the control subjects, the performance was improved only in animals stimulated 30 min. after the first learning session. No change was observed in animals stimulated 30 sec. or 3 hrs. post-trial. These results suggest that entorhinal cortex is involved rather late in memory processes.

摘要

在一项操作性条件反射任务后,于不同时间间隔对BALB/c小鼠的双侧内嗅皮层进行亚惊厥性刺激。24小时后,与对照组相比,仅在首次学习训练后30分钟接受刺激的动物中,其表现得到了改善。在试验后30秒或3小时接受刺激的动物中未观察到变化。这些结果表明,内嗅皮层在记忆过程中的参与相对较晚。

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