Galey D, Jeantet Y, Destrade C, Jaffard R
C R Seances Acad Sci III. 1982 May 3;294(16):841-4.
Sinusoidal (100Hz) electrical stimulation was applied at a weak intensity (7.5microA peak to peak) to the medial septal nucleus after partial acquisition of an appetitive operant conditioning task in a Skinner box. Analysis of performance recorded 24 hrs later during a retention session shows that (i) implantation alone impaired performance; (ii) electrical stimulation applied 30 sec. after the end of the acquisition session improves retention; this facilitatory effect disappears when the treatment is delayed 15 min. Furthermore spectral analysis of hippocampal EEG showed that there was no significant modification of theta rhythms. These results are discussed in relation to studies in the literature which demonstrate that RSA (rhythmical slow activity) is associated with memory-storage processes and our own hypothesis which underlines the importance of activation of septo-hippocampal cholinergic neurons in the early stages of these mnemonic processes.U
在斯金纳箱中部分获得操作性条件反射任务后，以弱强度（峰峰值7.5微安）对内侧隔核施加正弦（100赫兹）电刺激。对24小时后在保持期记录的行为表现进行分析表明：（i）仅植入电极会损害行为表现；（ii）在习得期结束后30秒施加电刺激可改善记忆保持；当治疗延迟15分钟时，这种促进作用消失。此外，海马脑电图的频谱分析表明，θ节律没有显著改变。结合文献中的研究对这些结果进行了讨论，这些研究表明节律性慢活动（RSA）与记忆存储过程相关，同时也结合了我们自己的假设，该假设强调在这些记忆过程的早期阶段，隔海马胆碱能神经元激活的重要性。
