Gauthier M, Destrade C
Brain Res. 1984 Sep 17;310(1):174-9. doi: 10.1016/0006-8993(84)90024-6.
In an appetitive learning task in mice, stimulation of the lateral entorhinal cortex (LEC) 30 min after training produced an improvement in retention 24 h later, as well as faster extinction of conditioning. This effect persisted in animals with bilateral lesions of the perforant path. In addition, the threshold for hippocampal after-discharges produced by LEC stimulation was raised significantly in perforant-path lesioned animals. The results indicate a functional dissociation between hippocampal and cortical mechanisms involved in memory consolidation.
在小鼠的一项味觉学习任务中，训练后30分钟刺激外侧内嗅皮层（LEC）可在24小时后改善记忆保持，同时加快条件反射的消退。这种效应在双侧穿通路径损伤的动物中依然存在。此外，在穿通路径损伤的动物中，由LEC刺激产生的海马后放电阈值显著提高。结果表明参与记忆巩固的海马和皮层机制之间存在功能分离。
