Rönnberg L
Int J Androl. 1980 Oct;3(5):479-86. doi: 10.1111/j.1365-2605.1980.tb00136.x.
In order to try to clarify the often supposed stimulating effect of clomiphene citrate on spermatogenesis a controlled double-blind cross-over trial was used. 30 pre-selected normogonadotropic infertile men were given 50 mg clomiphene citrate daily or placebo in a double-blind cross-over fashion for three months, each treatment period being separated by three to four months. On clomiphene treatment the median sperm count increased from 13.3 to 28.7 mill/ml (P < 0.001). During the placebo treatment schedules the median sperm count remained unchanged (P < 0.05). The increases of FSH, LH, testosterone, and oestradiol were highly significant (P < 0.001) during the clomiphene treatment but during placebo treatment the median hormone levels did not change (P < 0.05). Three pregnancies occurred due to clomiphene treatment and one occurred during placebo treatment.
为了试图阐明枸橼酸氯米芬对精子发生常被认为的刺激作用，采用了一项对照双盲交叉试验。30名预先选定的促性腺激素正常的不育男性以双盲交叉方式每日服用50毫克枸橼酸氯米芬或安慰剂，为期三个月，每个治疗期相隔三到四个月。在服用氯米芬治疗期间，精子计数中位数从1330万/毫升增加到2870万/毫升（P<0.001）。在安慰剂治疗期间，精子计数中位数保持不变（P<0.05）。在服用氯米芬治疗期间，促卵泡生成素、促黄体生成素、睾酮和雌二醇的升高非常显著（P<0.001），但在安慰剂治疗期间，激素中位数水平没有变化（P<0.05）。因服用氯米芬治疗有3例妊娠发生，在安慰剂治疗期间有1例妊娠发生。
