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正常受试者高密度脂蛋白胆固醇和载脂蛋白A-I水平的日内变化极小。

Minimal within-day variation of high density lipoprotein cholesterol and apolipoprotein A-I levels in normal subjects.

作者信息

Henderson L O, Saritelli A L, LaGarde E, Herbert P N, Shulman R S

出版信息

J Lipid Res. 1980 Sep;21(7):953-5.

PMID:6777443
Abstract

Blood was drawn from twenty normal hospital employees after a 12-14 hr fast (9:30 AM), and at 4 hr (1:30 PM) and 7 hr (4:30 PM) thereafter while test subjects consumed their habitual diet. Absorptive chylomicronemia was reflected in average triglyceride increases of 30% and 53% at 4 hr and 7 hr, respectively. No significant changes in total (< 1%) and high density lipoprotein (< 0.1%) cholesterol concentrations were observed. Moreover, levels of the major high density lipoprotein apolipoprotein, apoA-I, varied by less than 3%. Blood samples, randomly obtained during standard working hours, appear adequate for quantitation of high density lipoprotein cholesterol and apolipoprotein A-I levels.

摘要

在12 - 14小时禁食(上午9:30)后,采集了20名正常医院员工的血液,随后在测试对象按习惯饮食时,于4小时后(下午1:30)和7小时后(下午4:30)再次采血。吸收性乳糜微粒血症分别表现为4小时和7小时时甘油三酯平均升高30%和53%。未观察到总胆固醇(<1%)和高密度脂蛋白胆固醇(<0.1%)浓度有显著变化。此外,主要高密度脂蛋白载脂蛋白apoA - I的水平变化小于3%。在标准工作时间随机采集的血样似乎足以用于定量高密度脂蛋白胆固醇和载脂蛋白A - I水平。

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