Lawton N F, MacDermot J
J Neurol Neurosurg Psychiatry. 1980 Nov;43(11):1012-5. doi: 10.1136/jnnp.43.11.1012.
Levodopa with carbidopa suppressed prolactin release induced by thyrotrophin releasing hormone less effectively in patients with idiopathic Parkinson's disease than in normal subjects. This finding supports the view that the biochemical defect in idiopathic Parkinson's disease extends to the hypothalamus and is not confined to the basal ganglia. Aetiological considerations in Parkinson's disease should encompass a widespread disorder of neurotransmission whose extent merits further investigation.
左旋多巴与卡比多巴联合使用时，在特发性帕金森病患者中抑制促甲状腺激素释放激素诱导的催乳素释放的效果，不如在正常受试者中有效。这一发现支持了这样一种观点，即特发性帕金森病的生化缺陷延伸至下丘脑，而不仅限于基底神经节。帕金森病的病因学考量应涵盖一种广泛的神经传递障碍，其程度值得进一步研究。
