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Specific changes in Q-ribonucleoside containing transfer RNA species during Friend leukemia cell erythroid differentiation.弗氏白血病细胞红系分化过程中含Q-核糖核苷的转运RNA种类的特异性变化。
Nucleic Acids Res. 1980 Aug 11;8(15):3481-9. doi: 10.1093/nar/8.15.3481.
2
Alterations in tRNA isoaccepting species during erythroid differentiation of the Friend leukemia cell.弗氏白血病细胞红系分化过程中同功tRNA种类的变化
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Decoding the general role of tRNA queuosine modification in eukaryotes.解析真核生物中tRNA反密码子摇摆位点修饰的普遍作用。
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Differential heterocyclic substrate recognition by, and pteridine inhibition of E. coli and human tRNA-guanine transglycosylases.大肠杆菌和人 tRNA 鸟嘌呤转糖基酶对差异杂环碱基底物的识别及喋呤抑制作用。
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本文引用的文献

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Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide.体外小鼠病毒诱导白血病细胞中的血红蛋白合成：二甲基亚砜对红系分化的刺激作用
Proc Natl Acad Sci U S A. 1971 Feb;68(2):378-82. doi: 10.1073/pnas.68.2.378.
2
Possible anticodon sequences of tRNA His , tRNA Asm , and tRNA Asp from Escherichia coli B. Universal presence of nucleoside Q in the first postion of the anticondons of these transfer ribonucleic acids.来自大肠杆菌B的组氨酸tRNA、天冬酰胺tRNA和天冬氨酸tRNA的可能反密码子序列。这些转移核糖核酸的反密码子第一位普遍存在核苷Q。
Biochemistry. 1972 Jan 18;11(2):301-8. doi: 10.1021/bi00752a024.
3
A common change of aspartyl-tRNA in polyoma- and SV40 -transformed cells.多瘤病毒和SV40转化细胞中天冬氨酰-tRNA的常见变化。
Biochim Biophys Acta. 1972 Jul 31;272(4):568-82. doi: 10.1016/0005-2787(72)90512-6.
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Aspartyl transfer RNA profiles in normal and cancer cells.正常细胞和癌细胞中天冬氨酰转运RNA图谱
Cancer Res. 1972 Aug;32(8):1753-5.
5
Activity of a transfer RNA modifying enzyme during the development of Drosophila and its relationship to the su(s) locus.果蝇发育过程中一种转运RNA修饰酶的活性及其与su(s)基因座的关系。
J Mol Biol. 1973 Mar 15;74(4):635-51. doi: 10.1016/0022-2836(73)90054-5.
6
Regulation of an aspartyl-tRNA species in BHK cells in culture and in solid tumor form.培养的BHK细胞及实体瘤形式中一种天冬氨酰-tRNA种类的调控
Biochim Biophys Acta. 1975 Apr 2;383(4):441-5. doi: 10.1016/0005-2787(75)90314-7.
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Chromatographic and functional comparison of human placenta and HeLa cell tyrosine transfer ribonucleic acids.人胎盘与海拉细胞酪氨酸转移核糖核酸的色谱分析及功能比较
Biochemistry. 1976 Oct 19;15(21):4649-54. doi: 10.1021/bi00666a016.
8
Partial purification and properties of the reticulocyte guanylating enzyme.网织红细胞鸟苷酸化酶的部分纯化及性质
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9
Studies with a homogeneous enzyme from rabbit erythrocytes catalyzing the insertion of guanine into tRNA.对来自兔红细胞的一种催化鸟嘌呤插入tRNA的同功酶的研究。
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10
Comparison of rat liver and Walker 256 carcinosarcoma tRNAs.大鼠肝脏与Walker 256癌肉瘤转运RNA的比较。
Nucleic Acids Res. 1979 Feb;6(2):673-88. doi: 10.1093/nar/6.2.673.

弗氏白血病细胞红系分化过程中含Q-核糖核苷的转运RNA种类的特异性变化。

Specific changes in Q-ribonucleoside containing transfer RNA species during Friend leukemia cell erythroid differentiation.

作者信息

Lin V K, Farkas W R, Agris P F

出版信息

Nucleic Acids Res. 1980 Aug 11;8(15):3481-9. doi: 10.1093/nar/8.15.3481.

DOI:10.1093/nar/8.15.3481
PMID:6777758
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC324165/
Abstract

Changes in specific tRNA isoacceptors during Friend leukemia cell (F.L.C.) erythroid differentiation have been found to be concomitant with differences in the extent of the Q-base modification in certain species of tRNA. Transfer RNA was isolated from F.L.C. cultures after 0, 36, 48, 72, and 96 hr of DMSO induced differentiation. Changes in 17 isoacceptors of tRNAasn, tRNAasp, tRNAhis and tRNAtyr were compared by RPC-5 chromatography. Isoacceptors of these tRNA changed in relative amounts, following consistent trends throughout cell differentiation. The amount and distribution of Q-base containing tRNA isoacceptors was assayed by measuring the quanine-tRNA transferase catalyzed incorporation of [3H]-labeled guanine into tRNA species undermodified in Q-base followed by RPC-5 chormatography of the tRNA. The amount of Q-base containing tRNA species decreased in the first 48 hr after the induction, then increased again, indicating the level of Q-modification is correlated to the process of differentiation. Isoacceptors that lacked the Q-base were eluted late from RPC-5.

摘要

已发现，在弗瑞德白血病细胞（F.L.C.）红系分化过程中，特定tRNA同工受体的变化与某些tRNA物种中Q碱基修饰程度的差异相伴发生。在二甲基亚砜诱导分化0、36、48、72和96小时后，从F.L.C.培养物中分离出转移RNA。通过RPC - 5色谱法比较了tRNAasn、tRNAasp、tRNAhis和tRNAtyr的17种同工受体的变化。这些tRNA的同工受体相对含量发生变化，在整个细胞分化过程中呈现出一致的趋势。通过测量鸟嘌呤 - tRNA转移酶催化将[3H]标记的鸟嘌呤掺入Q碱基修饰不足的tRNA物种中，然后对tRNA进行RPC - 5色谱分析，来测定含Q碱基的tRNA同工受体的数量和分布。诱导后的前48小时内，含Q碱基的tRNA物种数量减少，然后再次增加，这表明Q修饰水平与分化过程相关。缺乏Q碱基的同工受体从RPC - 5中洗脱较晚。