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输血血清学中的外部质量控制:1976 - 1978年芬兰免疫血液学能力验证计划的结果

External quality control in blood transfusion serology: results from the Finnish proficiency testing programme in immunohaematology, 1976-1978.

作者信息

Rajamäki A, Pirkola A

出版信息

Scand J Clin Lab Invest. 1980 May;40(3):249-52. doi: 10.3109/00365518009095574.

DOI:10.3109/00365518009095574
PMID:6777854
Abstract

Results from the Finnish interlaboratory proficiency testing programme in immunohaematology from 1976 to 1978 are reviewed. The results show excellent accuracy of ABO grouping (100% correct). In Rh (D) grouping the detection of weak D antigen (Du) offered difficulties due to insufficient methodology. Also a sample from a donor with a positive direct antiglobulin reaction created confusion in Rh (D) grouping. The screening of atypical antibodies in serum was performed excellently (100% correct); the antibody coating of red cells, however, was detected by only 83.3% of the participants. The accuracy of compatible crossmatches was good (on average 98.7% correct); the accuracy of incompatible crossmatches, however, was poorer (on average 88.1% correct). A considerable methodological variation in compatibility testing is suggested to be responsible for the poor performance. The performance of individual laboratories seemed to correlate with their position in the health service organization, and with the level of internal quality control procedures.

摘要

回顾了1976年至1978年芬兰免疫血液学实验室间能力验证计划的结果。结果显示ABO血型分组的准确性极佳(100%正确)。在Rh(D)血型分组中,由于方法不足,弱D抗原(Du)的检测存在困难。此外,一名直接抗球蛋白反应呈阳性的献血者的样本在Rh(D)血型分组中造成了混淆。血清中非典型抗体的筛查执行得很好(100%正确);然而,只有83.3%的参与者检测到了红细胞上的抗体包被。相容性交叉配血的准确性良好(平均98.7%正确);不相容性交叉配血的准确性则较差(平均88.1%正确)。相容性检测中存在相当大的方法学差异被认为是导致表现不佳的原因。各个实验室的表现似乎与其在医疗服务组织中的地位以及内部质量控制程序的水平相关。

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