Mäkelä O, Pasanen V J, Sarvas H, Lehtonen M
Scand J Immunol. 1980;12(2):155-8. doi: 10.1111/j.1365-3083.1980.tb00052.x.
Mice of various strains were immunized with pneumococcal polysaccharide type 14 (pneumo-14), and their anti-pneumo-14 antibodies were measured by the Farr test. Mice of strains BALB/c, ST/b, NZB and CBA (Ig allotypes a, e or j) had 300-1700 ng of antibody nitrogen per millilitre of serum on day 7. The corresponding values for C57BL/Ka, RF or AKR mice (allotypes b, c or d) were 40-300 ng/ml. Two families of congenic strains were tested, one with the C57BL and the other with the BALB/c background genome. Their response was either high or low depending on the VH genes, and other gene loci had little effect on the concentration of anti-pneumo-14 antibodies.
用14型肺炎球菌多糖（肺炎-14）对多种品系的小鼠进行免疫，并通过Farr试验测定它们的抗肺炎-14抗体。BALB/c、ST/b、NZB和CBA品系（Ig同种异型a、e或j）的小鼠在第7天时每毫升血清中有300 - 1700纳克抗体氮。C57BL/Ka、RF或AKR小鼠（同种异型b、c或d）的相应值为40 - 300纳克/毫升。测试了两个同源近交系家族，一个具有C57BL背景基因组，另一个具有BALB/c背景基因组。它们的反应高低取决于VH基因，其他基因座对抗肺炎-14抗体浓度影响很小。
