[Integrated stimulation test with releasing hormones on healthy men and on patients with various forms of male hypogonadism].

Ninety subjects were examined; 20 healthy males, 20 patients with primary hypogonadism, 30 patients with Klinefelter's syndrome and 20 patients with secondary hypogonadism. The stimulating test with 200 mug LH-RH and 200 mug TTH was carried out tp all subjects examined, applied in two successive o.v. injections. The plasma as regards the levels of TTH, prolactin, FSH, LH, ACTH and STH is investigated every 0,20, 30, 60 and 90 minutes. The levels of tbe mentioned hormones were determined as well as the normal respond reaction. The basic LH and FSH levels are considerabty elevated in patients with primary hypogonadism and Klinefelter's syndrome and the respond reaction to stimulation is normal or diminished. A strict correlation between the number of X chromosomes and the level of FSH and LH was established in the patients with Klinefelter's syndrome. With respect to TTH, the basic, level in patients with primary hypogonadism in normal in 13 patients and pathological deviations were found in 7 patients. A strict correlation between TTH level and the number of X-chromosomes exists, Prolactin level in both groups is decreased. In patients with secondary hypogonadism the basic level of LH and ESH is decreased or at the lower limits of the norm. The respond reaction is absent. Both TTH and prolactin levels are pathologically changed as well as the respond reactions to stimulation depending on the etiology of the primary endocrine distrubance that had led to hypoginadism development.