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[多烯大环内酯类抗生素的分离方法]

[Method of partitioning polyene macrolide antibiotics].

作者信息

Golubeva L A, Kashkin A P, Shenin Iu D, Malkov M A, Larkin A I

出版信息

Antibiotiki. 1978 Jun;23(6):503-6.

PMID:677835
Abstract

Levorin and mycoheptin, polyenic antibiotics were separated into 3 and 7 heptaenic components respectively by the method of disc electrophoresis in 7.5 per cent polyacryl amide gel prepared with tris-HCl buffer, pH 8.9. It was shown that nystatin had different composition as dependent on the organism producing it. The results of electrophoresis confirmed the data of the counter-current distribution.

摘要

利佛菌素和制霉菌素,这两种多烯类抗生素,通过在pH值为8.9的Tris-HCl缓冲液配制的7.5%聚丙烯酰胺凝胶中进行圆盘电泳的方法,分别被分离成3种和7种七烯组分。结果表明,制霉菌素的组成因产生它的生物体不同而有所差异。电泳结果证实了逆流分配的数据。

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