Reznikova M I, Karpov V L, Dudnik Iu V, Bazhanov V S
Antibiotiki. 1978 Jul;23(7):609-11.
Distribution of 3H-carminomycin with the specific activity of 390 mCu/g prepared by the method of isotope exchange in 3H2O was investigated on mice treated with the antibiotic administered intravenously in a dose of 2 mg/kg. It was shown that the antibiotic rapidly accumulated in the mouse tissues, mainly in the liver, kidneys, lungs and spleen. The carminomycin blood levels markedly decreased within the first 5 minutes after the drug administration and remained rather stable during the following 6 hours. The concentrations of carminomycin in the heart muscle were comparatively low. Still, at early periods they were much higher than those in the skeletal muscles. The difference disappeared by 24 hours. Carminomycin penetrated into the tissues of the brain.
研究了通过在3H2O中进行同位素交换法制备的比活度为390 mCi/g的3H-卡米诺霉素在以2 mg/kg剂量静脉注射抗生素处理的小鼠体内的分布情况。结果表明，抗生素在小鼠组织中迅速蓄积，主要蓄积在肝脏、肾脏、肺和脾脏中。给药后最初5分钟内，卡米诺霉素的血药浓度显著下降，在随后的6小时内保持相对稳定。心肌中卡米诺霉素的浓度相对较低。不过，在早期，其浓度比骨骼肌中的浓度高得多。到24小时时，这种差异消失。卡米诺霉素可渗透到脑组织中。
