Zejc A, Pawlłowski M
Pol J Pharmacol Pharm. 1980 Mar-Apr;32(2):173-8.
The new obtained N3-alkyl- or arylpiperazinoalkyl substituted derivatives of 5,5-diphenylhydantoin weakly affect the spontaneous motility and the hypermotility induced by amphetamine. They did not show the anticonvulsive activity. Compounds containing the methyl (or phenyl)-piperazine moiety connected by the three-carbon chain with the N3 atom of the hydantoin ring show the strongest activity in the potentiation of the central effect of DOPA.
新得到的5,5-二苯基乙内酰脲的N3-烷基或芳基哌嗪基烷基取代衍生物对自发运动及由苯丙胺诱导的运动亢进影响较弱。它们未表现出抗惊厥活性。含有通过三碳链与乙内酰脲环的N3原子相连的甲基（或苯基）-哌嗪部分的化合物在增强多巴的中枢作用方面表现出最强活性。
