Derevenco P, Baciu I, Stoica N, Sovrea I, Vitebski V, Vaida A, Zdrenghea V
Physiologie. 1980 Jul-Sep;17(3):211-5.
In rats injected in the cerebral ventricle with 250 micrograms of 6-hydroxydopamine a significant blockade of the improvement of swimming performance due to training occurs. The central injection of 6-OHDA leads to a lengthening of the total latency time (LT) of active conditioned reaction in shuttle box and of the LT of netative escape responses during learning, but not of the positive avoidance responses. 6-OHDA injected after the learing schedule (12 days) has no effect on the LT during relearning and extinction. Therefore a partial destruction of central monoaminergic, and especially of dopaminergic, neurons impairs particularly the acquisition but not the retention of the motor program.
向大鼠脑室内注射250微克6-羟基多巴胺后，训练所带来的游泳性能改善会受到显著阻断。中枢注射6-羟基多巴胺会导致穿梭箱中主动条件反应的总潜伏期（LT）以及学习过程中阴性逃避反应的LT延长，但阳性回避反应的LT不受影响。在学习计划（12天）之后注射6-羟基多巴胺对再学习和消退过程中的LT没有影响。因此，中枢单胺能神经元，尤其是多巴胺能神经元的部分破坏，特别损害运动程序的获得，但不影响其保留。
