Kahng M W, Liu W, Sanefuji H, Resau J H, Heatfield B M, Trump B F
Chem Biol Interact. 1981 Mar 1;34(2):249-56. doi: 10.1016/0009-2797(81)90136-8.
Aryl hydrocarbon hydroxylase (AHH) was present in explant cultures of human prostate obtained from surgery of benign prostatic hyperplasia and was inducible by benz[a]anthracene (BA). The induction of AHH ranged from 14- to 150-fold when compared with control values and 10-fold variation of AHH inducibility among individuals was observed. Epithelial cells grown from human prostate tissue also contained measurable AHH activity and AHH was inducible by BA and 7,12-dimethylbenz[a]anthracene (DMBA). Inducibility of AHH by BA ranged from 2- to 63-fold. The inducibility of AHH by DMBA was always less than that by BA. In cells treated with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), there were no changes in AHH activity. These findings support the view that the human prostate is susceptible to environmental polycyclic hydrocarbon carcinogens and that environmental and occupational factors might contribute to the etiology of human prostatic carcinoma.
芳烃羟化酶（AHH）存在于从良性前列腺增生手术获取的人前列腺外植体培养物中，且可被苯并[a]蒽（BA）诱导。与对照值相比，AHH的诱导倍数在14至150倍之间，并且观察到个体间AHH诱导性存在10倍的差异。从人前列腺组织生长的上皮细胞也含有可测量的AHH活性，且AHH可被BA和7,12 - 二甲基苯并[a]蒽（DMBA）诱导。BA对AHH的诱导倍数在2至63倍之间。DMBA对AHH的诱导性总是低于BA。在用N - 甲基 - N'- 硝基 - N - 亚硝基胍（MNNG）处理的细胞中，AHH活性没有变化。这些发现支持了以下观点：人前列腺对环境多环烃致癌物敏感，并且环境和职业因素可能对人类前列腺癌的病因学有影响。
