Mahalik M P, Gautieri R F, Mann D E
J Pharm Sci. 1980 Jun;69(6):703-6. doi: 10.1002/jps.2600690625.
This investigation revealed that cocaine hydrochloride was teratogenic when administered in nontoxic doses to gravid CF-1 mice on Days 7-12 of gestation. The teratogenic susceptibility of the CF-1 mouse fetus to cocaine hydrochloride was evident throughout this portion of the gestation period. The early appearance of eye defects and the occurrence of skeletal defects later in gestation after cocaine hydrochloride challenge paralleled the sequence of ontogenesis.
这项研究表明,在妊娠第7至12天对妊娠CF-1小鼠给予无毒剂量的盐酸可卡因时,盐酸可卡因具有致畸性。在整个妊娠期的这一阶段,CF-1小鼠胎儿对盐酸可卡因的致畸易感性是明显的。盐酸可卡因刺激后,眼部缺陷的早期出现以及妊娠后期骨骼缺陷的发生与个体发生顺序相似。