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估算家鼠的全基因多样性。

Estimating total genic diversity in the house mouse.

作者信息

Bonhomme F, Selander R K

出版信息

Biochem Genet. 1978 Apr;16(3-4):287-97. doi: 10.1007/BF00484085.

DOI:10.1007/BF00484085
PMID:678296
Abstract

In a survey of variation in both electrophoretic charge and thermostability at 14 structural loci in 40 strains of Mus musculus, 27 electromorphs (polypeptides differing in electrophoretic charge) and 20 thermomorphs (polypeptides differing in thermostability) were found. Electrophoresis detected 11 new variants within thermomorphs, and the heat denaturation technique detected four new variants within electromorphs. From these data, and making the assumption that both techniques are independent of each other, it is estimated that the actual total number of alleles at the 14 loci is 53, or an average of 3.79 per locus (1.96 per electromorph), and that electrophoresis apparently detects one-third of the variants, thus describing about 50% of the alleles at structural gene loci in the house mouse.

摘要

在一项对40株小家鼠14个结构基因座上的电泳电荷和热稳定性变异的调查中,发现了27种电泳形态(电泳电荷不同的多肽)和20种热形态(热稳定性不同的多肽)。电泳在热形态中检测到11个新变体,热变性技术在电泳形态中检测到4个新变体。根据这些数据,并假设这两种技术相互独立,估计14个基因座上实际的等位基因总数为53个,平均每个基因座3.79个(每个电泳形态1.96个),并且电泳显然检测到了三分之一的变体,从而描述了家鼠结构基因座上约50%的等位基因。

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本文引用的文献

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PROTEIN POLYMORPHISM AND GENIC HETEROZYGOSITY IN TWO EUROPEAN SUBSPECIES OF THE HOUSE MOUSE.家鼠两个欧洲亚种中的蛋白质多态性与基因杂合性
Evolution. 1969 Sep;23(3):379-390. doi: 10.1111/j.1558-5646.1969.tb03522.x.
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Protein polymorphism and genic heterozygosity in a wild population of the house mouse (Mus musculus).家鼠(小家鼠)野生种群中的蛋白质多态性和基因杂合性。
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Isoallele frequencies in very large populations.非常大的群体中的等基因频率。
Biochem Genet. 1980 Apr;18(3-4):333-5. doi: 10.1007/BF00484245.
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Genetic analysis of protein variations in Mus musculus using two-dimensional electrophoresis.利用二维电泳对小家鼠蛋白质变异进行遗传分析。
Biochem Genet. 1980 Feb;18(1-2):185-97. doi: 10.1007/BF00504368.
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Frequency of thermostability variants: estimation of total "rare" variant frequency in human populations.热稳定性变异体的频率:人类群体中总“罕见”变异体频率的估计
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Selection at the alpha-Gpdh locus in experimental populations of Drosophila melanogaster.黑腹果蝇实验种群中α-甘油磷酸脱氢酶基因座的选择
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Biochemical diversity and evolution in the genus Mus.小家鼠属的生化多样性与进化
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Biochemical and immunological characterization of genetic variants of phosphoglucose isomerase from mouse.小鼠磷酸葡萄糖异构酶基因变体的生化与免疫学特性
Biochem Genet. 1980 Feb;18(1-2):153-69. doi: 10.1007/BF00504366.
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A polymorphic variant of the lactate dehydrogenase B subunit in the rat.
Genetica. 1987 May 15;72(1):65-8. doi: 10.1007/BF00126979.
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Recombinant congenic strains of mice from B10.D2 and DBA/2: their contribution to behavior genetic research and application to audiogenic seizures.源自B10.D2和DBA/2的重组近交系小鼠:它们对行为遗传学研究的贡献及在听源性癫痫中的应用
Behav Genet. 1992 Nov;22(6):685-701. doi: 10.1007/BF01066639.
Genetics. 1974 Mar;76(3):607-13. doi: 10.1093/genetics/76.3.607.
4
The probability of electrophoretic idendity of proteins as a function of amino acid divergence.蛋白质电泳同一性的概率作为氨基酸差异的函数。
J Mol Evol. 1973 Nov 27;2(4):317-22. doi: 10.1007/BF01654099.
5
A review of enzyme polymorphism, linkage and electrophoretic conditions for mouse and somatic cell hybrids in starch gels.小鼠及体细胞杂种在淀粉凝胶中的酶多态性、连锁关系及电泳条件综述。
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6
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7
Still more genetic variability in natural populations.自然种群中仍存在更多的遗传变异性。
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3928-31. doi: 10.1073/pnas.70.12.3928.
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